Dengue and blood platelets

4 Although binding of dengue to the dendritic cellspecific intracellular adhesion molecule-3grabbing nonintegrin DC-SIGN has been. Platelet count in dengue decreases as it suppresses bone marrow which is the platelet-producing area.

A summative report on the platelet count and its clinical correlation to duration of fever in 35 Thai children is presented.

Dengue and blood platelets. Dengue virus DENV infection causes 200 million cases of severe flulike illness annually escalating to life-threatening hemorrhagic fever or shock syndrome in 500000. Although thrombocytopenia is typical of both mild and severe diseases the mechanism triggering. Dengue virus binding to platelets involves DC-SIGN and HSP.

Platelets 5 10 5 mL were incubated for 30 minutes at A 4C B 25C or C 37C with PBS purified Fc TruStain FcX nonimmune isotype-matched control IgG anti-DC-SIGN LMW heparin chondroitin sulfate or a combination of LMWH and anti-DC-SIGN each at 50 μgmL. Dengue infection is a major vector-borne disease. The classical form of this infection has an incubation period of 5 to 8 days followed by fever violent headache and chills with rash developing after 3 to 4 days.

A summative report on the platelet count and its clinical correlation to duration of fever in 35 Thai children is presented. The thrombocytopenia in dengue is caused by the suppression of the platelet producing ability of the bone marrow the damage of platelets by blood cells affected by the dengue virus and the destruction of platelets by the antibodies produced by the body during a dengue infection. Blood platelets play an essential role in our bodies.

They are cell fragments that supplement growth and protect damaged blood vessels from bleeding and help recover from internal and external physical bruises. Every dengue patient is recommended. Platelets also known as thrombocytes are a component of blood.

Their primary function is to stop bleeding by clotting. They also have a role in defense mechanism by a process known as clumping or agglutination. The normal platelet count in humans ranges from 15 to 4 lakh.

In dengue platelet count can drastically fall below 15 lakh. Platelet count in dengue decreases as it suppresses bone marrow which is the platelet-producing area. Platelets count in dengue decreases because of Blood cells affected by the disease virus damage platelets.

Antibodies that are produced during this period leads to massive destruction of platelets in dengue. Subsequently the platelet count is the number of platelets in the blood. A normal platelet count ranges from 150000 to 350000.

But during dengue the platelet count starts declining at a rapid pace. Let us read more about the platelet count during dengue below. How to Increase Platelet Count in Dengue With Fibers Vitamins.

To ensure good health a high and stable platelet count in your body. Dengue virus does not attack the blood platelets. The latter are destroyed due to autoimmune reaction induced as a result of infection by dengue virus.

Dengue viral RNA was detected in the platelets and plasma by conventional RT-PCR and EM which confirmed the presence of dengue viral-like particles inside platelets isolated from patients. These data suggested that the presence of DENV in platelets might be associated with platelet dysfunction. Blood platelets are a vital component in human body.

Also known as Thrombocytes it plays a crucial role in the process of Hemostasis that stops bleeding when a blood vessel ruptures. In 1 µL of blood in human body the normal platelet count is 150000 to 450000. Patients suffering from dengue tends to be free from fever first and the only thing they needed to monitor is the blood platelet count so it is indeed a must that one must know how to increase them before they drop real low.

A normal blood platelet count is 150 and above. A typical person has a platelet count of between 150000 and 250000 per microlitre of blood. About 80 to 90 per cent of patients with dengue will have levels below 100000 while 10 to 20 per cent of patients will see critically low levels of 20000 or less.

In a recent paper the team discovered the cause of one of the major symptoms of dengue fever the depletion of blood platelets which are essential to proper blood clotting. The finding could help scientists come up with new ways to treat dengue says Jianzhu Chen the Ivan R. Cottrell Professor of Immunology at MIT a member of MITs.

High fever headache joint pain and eye pain are the main symptoms of dengue. You can go for a checkup or blood test and can know whether you are suffering from common fever or dengue your blood platelets starts decreasing rapidly as soon as you become a victim of dengue. If there is a lot of reduction in platelets then a person can even die.

Recent studies have shown that dengue induces platelet activation and apoptosis which modulate inflammatory responses in target monocytes. 23 Additionally dengue infection triggers the synthesis and release of interleukin-1β IL-1β by human platelets. 4 Although binding of dengue to the dendritic cellspecific intracellular adhesion molecule-3grabbing nonintegrin DC-SIGN has been.

A Platelet number was measured from freshly isolated blood samples of dengue patients n 19 at different days of fever 4 6 8 and 10 and of healthy controls n. It can lead to the more severe dengue haemorrhagic fever. One of the complications of this is a sudden fall in blood platelet count.

If the situation is not reversed immediately it can even lead. Platelet counts are only part of the complete blood count which are one of the laboratory and diagnostic work ups in dengue and each one platelets red blood cells white blood cells hematocrit etc may very well have some interesting stuff happening in the molecular level a bit long to elaborate. Dengue Management DOs and DONTs X DONT use corticosteroids.

They are not indicated and can increase the risk of GI bleeding hyperglycemia and immunosuppression. X DONT give platelet transfusions for a low platelet count. Platelet transfusions do not decrease the risk of severe bleeding and may instead lead to fluid overload and.

Why is the demand for platelets so high. The platelet count in a healthy adult ranges from 150000 to 400000 per microlitre of blood. But when a dengue patient gets haemorrhagic fever it causes damage to the lymphatic system and blood vessels promoting bleeding from the nose and gums.

Platelets were isolated as previously described 3347Briefly peripheral blood samples were drawn into anticoagulant acid-citrate-dextrose ACD and centrifuged at 200 g.